The Substance 2025 Cast Members. “the substance” (2024), directed by coralie fargeat, is a provocative body horror comedy that delves into the perils of vanity and the quest for eternal youth. With that in mind, here is a breakdown of the small cast of characters that appear in the substance.

Demi moore stars as elisabeth sparkle, a hollywood actress who has a star on the walk of fame,. Elisabeth sparkle, a fading celebrity, turns to a mysterious drug that promises to restore her youth by creating a younger, more beautiful version of herself.